Wegovy vs Mounjaro is a key question for many people in the UK seeking effective weight loss support. With obesity linked to serious long-term risks such as heart disease, stroke, and diabetes, injectable medicines have become an important option for those who struggle with weight management.
Among the most widely discussed treatments are Wegovy and Mounjaro, two prescription-only injections that work in different ways but share the goal of supporting sustainable weight loss. This blog looks at the latest evidence to help you understand the differences.
What Are Wegovy and Mounjaro?
Wegovy and Mounjaro are both prescription-only medicines used for managing weight. They work differently in the body but share the aim of helping patients achieve and maintain weight loss.
Understanding how each works makes it easier to see which option may be more suitable.
How Wegovy Works
Wegovy contains semaglutide, which mimics GLP-1 (glucagon-like peptide-1), a hormone that regulates appetite. It helps people feel fuller for longer, which can lead to reduced calorie intake.
How Mounjaro Works
Mounjaro contains tirzepatide, which targets two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), linked to appetite and blood sugar control. This dual action may provide an additional benefit for some patients.
Key Differences Between Them
The main difference lies in their mechanisms. Wegovy focuses on appetite regulation, while Mounjaro has a broader effect on both appetite and metabolism. The main difference lies in their mechanisms. Wegovy focuses on appetite regulation, while Mounjaro has a broader effect on both appetite and metabolism.
Effectiveness in Weight Management
Both injections have shown promising results for weight management, though outcomes vary by individual. Let’s look at what reviews and clinical trials reveal about their effectiveness.
What Wegovy Reviews Suggest
Wegovy reviews often highlight consistent weight loss results, especially when combined with healthy lifestyle changes.
What Mounjaro Reviews Highlight
Mounjaro reviews suggest it may deliver slightly greater weight reduction in some cases, though real-world comparisons are still developing.
Clinical Trial Evidence
In May 2025, a major study published in the New England Journal of Medicine compared semaglutide (Wegovy) with tirzepatide (Mounjaro) in people living with obesity but without type 2 diabetes.
- Participants on Mounjaro lost an average of 20.2% of body weight.
- Participants on Wegovy lost an average of 13.7% of body weight.
- Waist measurements also reduced more significantly with Mounjaro.
These findings suggest tirzepatide may deliver greater overall weight reduction, though researchers stress that more evidence is needed to confirm long-term benefits, especially for heart health.
Weight Loss Medication Side Effects
Like all medicines, Wegovy and Mounjaro may cause side effects. Let’s look at the most common and serious reactions and how they can be managed safely.
Common Side Effects
Nausea, diarrhoea, constipation, and stomach discomfort are the most frequently reported side effects for both medicines.
Serious but Less Common Side Effects
In rare cases, issues such as pancreatitis or gallbladder problems may occur. These require urgent medical attention.
Managing Side Effects Safely
In the 2025 study, around 77–79% of participants experienced at least one side effect, though most were mild to moderate. Starting with a lower dose and gradually increasing under professional supervision can help manage tolerance.
Who Might Be Suitable for Wegovy or Mounjaro?
Suitability depends on individual health and professional assessment. In the UK, these medicines are prescribed under NHS or private guidelines for people with obesity or certain weight-related conditions.
Factors such as diabetes, cardiovascular risk, or current medication use may influence which option is more appropriate. If you are considering weight loss injections, always consult a qualified healthcare professional to confirm eligibility and safety.
Wegovy vs Mounjaro – Final Comparison
Wegovy and Mounjaro both support weight management, but the right choice depends on personal health factors.
Weight Loss Injection Comparison at a Glance
- Wegovy: Focuses on appetite control
- Mounjaro: Targets appetite and blood sugar regulation
- Both: Proven to aid weight loss alongside lifestyle changes
Which Option May Be Right for You?
There is no single answer when it comes to choosing between Wegovy and Mounjaro. The right option depends on your health history, current conditions, and personal goals, which is why a professional consultation is essential.
Weight Loss Support at Ham Pharmacy Group
At Ham Pharmacy Group, we are committed to supporting safe and sustainable weight management. Our trained pharmacists provide private weight loss services, helping you understand the best approach for your needs.
To get started, you can book a confidential consultation with our pharmacists at our two pharmacies: Ham Parade or Ham Village. We’ll assess your needs and discuss all appropriate options.
